HPTLC Screening and Alpha-Glucosidase Inhibitory Activity of Ethanolic Extract of Marang (Artocarpus odoratissimus) Core Waste Fruit
DOI:
https://doi.org/10.7719/jpair.v64i1.989Keywords:
Health Sciences, Artocarpus odoratissimus extract, alpha-glucosidase inhibition, phytochemical, antidiabetic activity, quantitative-experimental, PhilippinesDisciplines:
Pharmacognosy, PhytochemistryAbstract
Marang (Artocarpus odoratissimus) is a native Philippine tree commonly found in Southeast Asia, used to treat various ailments. To provide a scientific basis for such a claim, this study evaluated the potential of marang, focusing on the core waste fruit, as a natural treatment for diabetes that aligns with the Sustainable Development Goals and the circular economy by reducing resource waste and minimizing environmental impact. This study utilized a quantitative, descriptive, comparative, and experimental design to analyze data on the phytochemical constituents and alpha-glucosidase inhibitory activity. For the evaluation of glucosidase inhibition activity, in vitro methods, and statistical such as mean, standard deviation, One-Way ANOVA, Regression and Post Hoc were applied. HPTLC screening revealed the presence of primary metabolites, including proteins, suggesting possible medicinal properties. Results showed a statistically significant difference (p<0.05) at the 95% confidence level between acarbose and marang core waste fruit extract. The IC50 of the extract of marang core waste fruit shows (203±4.15ug/mL), demonstrating a significant difference to acarbose (125±0.48 ug/mL). Overall, the findings showed that the marang core waste fruit is a potential alternative herbal medicine as an alpha-glucosidase inhibitor for diabetes.
Downloads
References
Abed, E., Jarrar, Y., Alhawari, H., Abdullah, S., & Zihlif, M. (2022). The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients. Drug Metabolism and Personalized Therapy, 37(2), 149-154. https://doi.org/10.1515/dmpt-2021-0164
Alvarado, M. C. (2023). Marang fruit (ArtocarpusOdoratissimus) waste: A promising resource for food and diverse applications: A review of its current status, research opportunities, and future prospects. Food Bioengineering, 2(4), 350-359. https://doi.org/10.1002/fbe2.12065
Atkinson, M., Williams, D. M., Crockett, E., Hathaway, I., Mon, M., Stephens, J. W., & Min, T. (2025). Assessing glycaemic impact of FreeStylelibre monitoring in patients with insulin-treated type 2 diabetes: a retrospective real-world analysis. Journal of Diabetes & Metabolic Disorders, 24(1), 1-8. https://doi.org/10.1007/s40200-025-01572-1
Published
Issue
Section
License
Copyright (c) 2026 Aileen L. Cabantac
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Open Access. This article published by JPAIR Multidisciplinary Research is licensed under a Creative Commons Attribution-Noncommercial 4.0 International (CC BY-NC 4.0). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material). Under the following terms, you must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
